# Question Answer
1 Anemia (hemoglobin <100g/L)
2 Leucocytosis >25x109/L
3 Thrombocytopenia (platelet count <100x109/L)
4 Peripheral blood blast count ≥2%
5 Bone marrow fibrosis grade ≥2
6 Constitutional symptoms
7 Absence of CALR type 1/like mutation
8 HMR* category
9 ≥2 HMR mutated genes
10 Unfavorable karyotype**
 
Score Result
MIPSS70 LOW RISK [5-year OS= 96%] INTERMEDIATE RISK [5-year OS= 67%] HIGH RISK [5-year OS= 34%]
MIPSS70-plus LOW RISK [5-year OS= 100%] INTERMEDIATE RISK [5-year OS= 90%] HIGH RISK [5-year OS= 76%] VERY HIGH RISK [5-year OS= 46%] NOT AVAILABLE