# Question Answer
1 Severe Anemia (hemoglobin <80g/L)
2 Moderate Anemia (hemoglobin 80-100g/L)
3 Leucocytosis >25x109/L
4 Thrombocytopenia (platelet count <100x109/L)
5 Peripheral blood blast count ≥2%
6 Bone marrow fibrosis grade ≥2
7 Constitutional symptoms
8 Absence of CALR type 1/like mutation
9 HMR1 category
10 ≥2 HMR mutated genes
11 Unfavorable karyotype2
12 Very High Risk karyotype3
Score Result
MIPSS70 LOW RISK [5-year OS= 96%] INTERMEDIATE RISK [5-year OS= 67%] HIGH RISK [5-year OS= 34%]
MIPSS70-plus version 2.0 VERY LOW RISK [10-year OS= 92%] LOW RISK [10-year OS= 56%] INTERMEDIATE RISK [10-year OS= 37%] HIGH RISK [10-year OS= 13%] VERY HIGH RISK [10-year OS< 5%] NOT AVAILABLE